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Bioactive inorganic materials/alginate composite microspheres with controllable drug-delivery ability

Wu, Chengtie, Zhu, Yufeng, Chang, Jiang, Zhang, Yufeng, & Xiao, Yin (2010) Bioactive inorganic materials/alginate composite microspheres with controllable drug-delivery ability. Journal of Biomedical Materials Research Part B : Applied Biomateraials, 94(1), pp. 32-43.

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Abstract

Alginate microspheres are considered a promising material as a drug carrier in bone repair due to excellent biocompatibility, but their main disadvantage is low drug entrapment efficiency and non-controllable release. The aim of this study was to investigate the effect of incorporating mesoporous bioglass (MBG), non-mesoporous bioglass (BG) or hydroxyapatite (HAp) into alginate microspheres on their drug-loading and release properties. X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and atomic emission spectroscopy (AES) were used to analyse the composition, structure and dissolution of bioactive inorganic materials and their microspheres. Dexamethasone (DEX)-loading and release ability of four microspheres were tested in phosphate buffered saline with varying pHs. Results showed that the drug-loading capacity was enhanced with the incorporation of bioactive inorganic materials into alginate microspheres. The MBG/Alginate microspheres had the highest drug loading ability. DEX release from alginate microspheres correlated to the dissolution of MBG, BG and HAp in PBS, and that the pH was an efficient factor in controlling the DEX release; a high pH resulted in greater DEX release, whereas a low pH delayed DEX release. In addition, MBG/alginate, BG/alginate and HAp/alginate microspheres had varying apatite-formation and dissolution abilities, which indicate that the composites would behave differently with respect to bioactivity. The study suggests that microspheres made of a composite of bioactive inorganic materials and alginate have a bioactivity and degradation profile which greatly improves their drug delivery capacity, thus enhancing their potential applications as bioactive filler materials for bone tissue regeneration.

Impact and interest:

12 citations in Scopus
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9 citations in Web of Science®

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365 since deposited on 27 Apr 2010
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ID Code: 32020
Item Type: Journal Article
Additional URLs:
Keywords: Drug release, Mesopore bioglass, Bioactivity Alginate, Biomaterials, Tissue regeneration
DOI: 10.1002/jbm.b.31621
ISSN: 1552-4973
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2010 John Wiley & Sons, Inc.
Copyright Statement: The definitive version is available at www3.interscience.wiley.com
Deposited On: 28 Apr 2010 08:59
Last Modified: 01 Mar 2012 00:16

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