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Mechanical And Electrical Environments To Stimulate Bone Cell Development

Hannay, Gwynne G., Leavesley, David I., & Pearcy, Mark J. (2005) Mechanical And Electrical Environments To Stimulate Bone Cell Development. In 11th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society, Perth, Australia.

Abstract

Oral Presentation - no full written paper: The aim of this project was to evaluate the effects of mechanical strain and indirect electrical stimulation upon the development of bone forming osteoblast cells and any possible synergistic effects of the two stimulants. This aim was achieved by using a novel device, designed and developed with the capability of creating a cell substrate surface strain along with an exogenous electrical stimulant individually or at the same time. Proliferation and differentiation was determined as a measure of cellular development. The indirect electrical stimulation was achieved through the use of pulsed electromagnetic field (PEMF) stimulation while the mechanical strain was produced from the dynamic stretching of a deformable cell substrate. The PEMF signal mimicked a clinically available bone growth stimulator signal. Results showed reduced proliferation and increased differentiation (alkaline phosphatase activity) with SaOS-2 osteoblast-like cell cultures, which were exposed to indirect electrical stimulation. MG-63 osteoblast-like cell cultures also showed reduced proliferation, however they did not show an increase in their differentiation with PEMF exposure. Mechanical stimulation alone did not have a significant effect over either proliferation or differentiation, while a dual mechanical and electrical stimulation resulted in cellular differentiation significantly increasing. It is possible a synergistic interaction between the two stimulants is occurring on a biological level.

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ID Code: 3212
Item Type: Conference Paper
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL PHYSIOLOGY (111600)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL PHYSIOLOGY (111600) > Cell Physiology (111601)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2005 (please consult author)
Deposited On: 06 Feb 2006
Last Modified: 11 Aug 2011 00:30

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