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Bacterial proteases from the intracellular vacuole niche ; protease conservation and adaptation for pathogenic advantage

Huston, Wilhelmina M. (2010) Bacterial proteases from the intracellular vacuole niche ; protease conservation and adaptation for pathogenic advantage. F E M S Immunology and Medical Microbiology, 59(1), pp. 1-10.

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Abstract

Proteases with important roles for bacterial pathogens which specifically reside within intracellular vacuoles are frequently homologous to those which have important virulence functions for other bacteria. Research has identified that some of these conserved proteases have evolved specialised functions for intracellular vacuole residing bacteria. Unique proteases with pathogenic functions have also been described from Chlamydia, Mycobacteria, and Legionella. These findings suggest that there are further novel functions for proteases from these bacteria which remain to be described. This review summarises recent findings of novel protease functions from the intracellular human pathogenic bacteria which reside exclusively in vacuoles.

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6 citations in Scopus
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5 citations in Web of Science®

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129 since deposited on 14 May 2010
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ID Code: 32220
Item Type: Journal Article
Additional URLs:
Keywords: protease, intracellular, pathogen
DOI: 10.1111/j.1574-695X.2010.00672.x
ISSN: 0928-8244
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Enzymes (060107)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Wiley-Blackwell Publishing Ltd
Deposited On: 14 May 2010 10:38
Last Modified: 01 Mar 2012 00:25

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