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HtrA, RseP, and Tsp do not elicit a pathology related serum IgG response during sexually transmitted infection with Chlamydia trachomatis

Huston, Wilhelmina M., Armitage, Charles, Lawrence, Amba, Gloeckl, Sarina, Bell, Steven, Debattista, Joseph, Allan, John, & Timms, Peter (2010) HtrA, RseP, and Tsp do not elicit a pathology related serum IgG response during sexually transmitted infection with Chlamydia trachomatis. Journal of Reproductive Immunology.

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Abstract

Chlamydia trachomatis sexually transmitted infection can cause serious reproductive morbidities. This study determined the prevalence of serum IgG response to C. trachomatis putative stress response proteins in females to test for an association with genital tract pathology. There was no significant association of serum IgG to HtrA, Tsp, or RseP with infection or pathology. cHSP60 serum IgG prevalence was significantly associated with infection compared to negative (infertile) controls (p = 0.002), but not with upper genital tract pathology. Serum IgG1-4 antibody subclasses reactive with the antigens was not significantly different between cohorts, although different responses to each antigen were detected.

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4 citations in Scopus
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3 citations in Web of Science®

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ID Code: 32221
Item Type: Journal Article
Additional URLs:
DOI: 10.1016/j.jri.2010.02.007
ISSN: 0165-0378
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > IMMUNOLOGY (110700) > Humoural Immunology and Immunochemistry (110705)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Elsevier Ireland Ltd
Deposited On: 14 May 2010 10:27
Last Modified: 01 Mar 2012 00:15

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