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The return of a forgotten polymer : Polycaprolactone in the 21st century

Woodruff, Maria A. & Hutmacher, Dietmar W. (2010) The return of a forgotten polymer : Polycaprolactone in the 21st century. Progress in Polymer Science, 35(10), pp. 1217-1256.

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Abstract

During the resorbable-polymer-boom of the 1970s and 1980s, polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices. Its popularity was soon superseded by faster resorbable polymers which had fewer perceived disadvantages associated with long term degradation (up to 3-4 years) and intracellular resorption pathways; consequently, PCL was almost forgotten for most of two decades. Recently, a resurgence of interest has propelled PCL back into the biomaterials-arena. The superior rheological and viscoelastic properties over many of its aliphatic polyester counterparts renders PCL easy to manufacture and manipulate into a large range of implants and devices. Coupled with relatively inexpensive production routes and FDA approval, this provides a promising platform for the production of longer-term degradable implants which may be manipulated physically, chemically and biologically to possess tailorable degradation kinetics to suit a specific anatomical site. This review will discuss the application of PCL as a biomaterial over the last two decades focusing on the advantages which have propagated its return into the spotlight with a particular focus on medical devices, drug delivery and tissue engineering.

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320 citations in Web of Science®

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ID Code: 32270
Item Type: Review
Keywords: polymer, polycaprolactone, biomaterial, resorbable, scaffold
DOI: 10.1016/j.progpolymsci.2010.04.002
ISSN: 0079-6700
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Elsevier
Deposited On: 28 May 2010 08:21
Last Modified: 01 Mar 2012 00:21

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