Human osteoblast cell spreading and vinculin expression upon biomaterial surfaces

Woodruff, Maria A., Jones, Peter, Farrar, David, Grant, David, & Scotchford, Colin (2007) Human osteoblast cell spreading and vinculin expression upon biomaterial surfaces. Journal of Molecular Histology, 38(5), pp. 491-499.

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Any biomaterial implanted within the human body is influenced by the interactions that take place between its surface and the surrounding biological milieu. These interactions are known to influence the tissue interface dynamic, and thus act to emphasize the need to study cell-surface interactions as part of any biomaterial design process. The work described here investigates the relationship between human osteoblast attachment, spreading and focal contact formation on selected surfaces using immunostaining and digital image processing for vinculin, a key focal adhesion component. Our observations show that a relationship exists between levels of cell attachment, the degree of vinculin-associated plaque formation and biocompatibility. It also suggests that cell adhesion is not indicative of how supportive a substrate is to cell spreading, and that cell spreading

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16 citations in Web of Science®

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ID Code: 32416
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: osteoblast, bone, cell-surface
DOI: 10.1007/s10735-007-9142-1
ISSN: 1567-2379
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Springer Netherlands
Deposited On: 27 May 2010 23:22
Last Modified: 29 Feb 2012 14:02

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