25th anniversary of BUA for the assessment of osteoporosis : time for a new paradigm?
Langton, Christian M. (2010) 25th anniversary of BUA for the assessment of osteoporosis : time for a new paradigm? .
The Measurement of Broadband Ultrasonic Attenuation (BUA) in cancellous bone at the calcaneus for the assessment of osteoporosis was first described within this journal 25 years ago. It was recognized in 2006 by Universities UK as being one of the “100 discoveries and developments in UK Universities that have changed the world” over the past 50 years. In 2008, the UK’s Department of Health also recognised BUA assessment of osteoporosis in a publication highlighting eleven projects that have contributed to ‘60 years of NHS research benefiting patients’. The BUA technique has been extensively clinically validated and is utilised Worldwide, with at least seven commercial systems currently providing calcaneal BUA measurement. However, there still lacks a fundamental understanding of the dependence of BUA upon the material and structural properties of cancellous bone. This review aims to provide an ‘Engineering in Medicine’ perspective and proposes a new paradigm based upon phase-cancellation due to variation in propagation transit time across the receive transducer face to explain the non-linear relationship between BUA and bone volume fraction in cancellous bone.
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|Item Type:||Journal Article|
|Additional Information:||This article is submitted to "Journal Of Engineering In Medicine - Part H" for publishing.|
|Keywords:||Bone, Ultrasound, Osteoporosis, Signal Processing|
|Subjects:||Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Medical Physics (029903)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Physics
|Copyright Owner:||Copyright 2010 Christian M. Langton|
|Deposited On:||08 Jun 2010 08:00|
|Last Modified:||22 Jun 2011 00:59|
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