25th anniversary of BUA for the assessment of osteoporosis : time for a new paradigm?

Langton, Christian M. (2011) 25th anniversary of BUA for the assessment of osteoporosis : time for a new paradigm? Institution of Mechanical Engineers. Proceedings. Part H: Journal of Engineering in Medicine, 225(2), pp. 113-125.

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The measurement of broadband ultrasonic attenuation (BUA) in cancellous bone at the calcaneus for the assessment of osteoporosis was first described within this journal 25 years ago. It was recognized in 2006 by Universities UK as being one of the ‘100 discoveries and developments in UK Universities that have changed the world’ over the past 50 years. In 2008, the UK's Department of Health also recognized BUA assessment of osteoporosis in a publication highlighting 11 projects that have contributed to ‘60 years of NHS research benefiting patients’. The BUA technique has been extensively clinically validated and is utilized worldwide, with at least seven commercial systems currently providing calcaneal BUA measurement. However, there is still no fundamental understanding of the dependence of BUA upon the material and structural properties of cancellous bone. This review aims to provide an ‘engineering in medicine’ perspective and proposes a new paradigm based upon phase cancellation due to variation in propagation transit time across the receive transducer face to explain the non-linear relationship between BUA and bone volume fraction in cancellous bone.

Impact and interest:

11 citations in Scopus
11 citations in Web of Science®
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302 since deposited on 07 Jun 2010
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ID Code: 32523
Item Type: Journal Article
Refereed: Yes
Keywords: Bone, Ultrasound, Osteoporosis, Signal Processing
DOI: 10.1243/09544119JEIM777
ISSN: 0954-4119
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Medical Physics (029903)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Physics
Copyright Owner: Copyright 2010 Christian M. Langton
Deposited On: 07 Jun 2010 22:00
Last Modified: 07 Sep 2013 04:25

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