Red clover (Trifolium pratense) isoflavones and serum homocysteine in premenopausal women : a pilot study

Samman, Samir, Koh, Hoon Siang, Flood, Victoria, Blakesmith, Sarah, Petocz, Peter, & Lyons-Wall, Philippa (2009) Red clover (Trifolium pratense) isoflavones and serum homocysteine in premenopausal women : a pilot study. Journal of Women's Health, 18(11), pp. 1813-1816.

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Background: There is limited information on the effect of isoflavones on homocysteine concentrations, a risk factor for a number of chronic diseases.

Methods: Twenty-three premenopausal women participated in a double-blind, randomized, parallel study for four menstrual cycles. Subjects consumed either placebo or purified red clover (Trifolium pratense) isoflavone (86mg/day) tablets. Blood samples were collected weekly during cycles 1, 3, and 4 for determination of serum folate and total homocysteine concentrations. Dietary intake was monitored monthly.

Results: Concentrations of folate and homocysteine in serum did not change significantly in either group, and there were no significant differences observed between the follicular and luteal phases of the menstrual cycle. The participants' dietary records indicated that nutrient intake was constant, and compliance was confirmed by analysis of urinary isoflavone concentrations and tablet counts in returned containers.

Conclusions: These results suggest that in the absence of any dietary modification, supplementation with purified isoflavones that are predominantly methoxylated has no effect on serum homocysteine or folate in premenopausal women.

Impact and interest:

3 citations in Scopus
1 citations in Web of Science®
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ID Code: 32898
Item Type: Journal Article
Refereed: Yes
DOI: 10.1089/jwh.2008.1201
ISSN: 1540-9996
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 23 Jun 2010 21:55
Last Modified: 10 Jul 2017 21:01

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