Effect of prostaglandin-inhibitor naproxen on the corneal swelling response to hydrogel contact lens wear

Efron, Nathan, Holden, Brien A., & Vannas, Antti (1984) Effect of prostaglandin-inhibitor naproxen on the corneal swelling response to hydrogel contact lens wear. Acta Ophthalmologica Scandinavica, 62(5), pp. 746-752.


Previous studies have demonstrated that the prostaglandin-inhibitor naproxen can reduce post-surgical corneal oedema, which is largely due to an inflammatory process. To determine whether there is an inflammatory component in the oedematous response of the cornea to contact lens wear, we conducted a randomized, double-masked, placebo-controlled study on the effect of naproxen on contact lens-induced corneal swelling. This drug did not have a significant effect, suggesting that prostaglandins are not involved in the hypoxic oedema response. The discrepancy between the effect of naproxen on lens- and surgically-induced corneal oedema can be attributed to the different aetiologies of these oedema responses.

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9 citations in Scopus
8 citations in Web of Science®
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ID Code: 3338
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: n.efron@qut.edu.au
Additional URLs:
Keywords: Contact Lenses/, adverse effects, Corneal Diseases/, prevention & control, Edema/, prevention & control, Naproxen/, therapeutic use, Adolescent, Adult, Clinical Trials, Corneal Diseases/etiology, Edema/etiology, Female, Humans, Male, Naproxen/pharmacology, Prostaglandin Antagonists
ISSN: 1395-3907
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1984 Blackwell Publishing
Deposited On: 03 Feb 2006 00:00
Last Modified: 10 Aug 2011 14:42

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