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Direct in vivo measurement of corneal epithelial metabolic activity using a polarographic oxygen sensor

Holden, Brien A. , Sulonen, Jukka, Vannas, Antti, Sweeney, Deborah F. , & Efron, Nathan (1985) Direct in vivo measurement of corneal epithelial metabolic activity using a polarographic oxygen sensor. Ophthalmic research, 17(3), pp. 168-173.

Abstract

The component oxygen fluxes that constitute a single recording of corneal oxygen uptake when a polarographic oxygen sensor (POS) is placed in contact with the cornea were determined in the in vivo rabbit eye by removing the epithelium and injecting an air bubble into the anterior chamber. The relative contribution of epithelial oxygen consumption, stromal oxygen consumption and diffusion were approximately 55, 5 and 40%, respectively. It is demonstrated that differences in corneal oxygen uptake rates recorded with a POS primarily indicate differences in epithelial metabolic activity. Changes in epithelial metabolism can be determined by measuring both corneal oxygen uptake and corneal thickness. For example, if corneal thickness is constant, differences in epithelial oxygen flux (a) between two eyes of one person, or (b) before and after a procedure in the same eye, can be calculated by multiplying the difference in oxygen consumption measured with a POS by a factor of 1.8.

Impact and interest:

2 citations in Scopus
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ID Code: 3347
Item Type: Journal Article
Additional Information: For more information, please refer to the journal's website (see link) or contact the author. Author contact details: n.efron@qut.edu.au
Additional URLs:
Keywords: Oxygen Consumption, Cornea/, metabolism, Polarography/, instrumentation, Animals, Epithelium/metabolism, Mathematics, Rabbits, Research Support, Non, U, S, Gov't
ISSN: 0030-3747
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1985 Karger
Deposited On: 08 Feb 2006
Last Modified: 11 Aug 2011 03:43

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