Strategies for minimizing the ocular effects of extended contact lens wear--a statistical analysis

Holden, Brien A., Swarbrick, Helen A., Sweeney, Deborah A., Ho, Arthur, Efron, Nathan, Vannas, Antti, & Nilsson, Klas T. (1987) Strategies for minimizing the ocular effects of extended contact lens wear--a statistical analysis. American journal of optometry and physiological optics, 64(10), pp. 781-789.


In a study reported recently, the effects of long-term extended wear of soft contact lenses on the human cornea were found to include epithelial thinning, a reduction in epithelial oxygen uptake, induction of epithelial microcysts, stromal thinning, and an increase in endothelial polymegathism. A multiple regression analysis was performed on data from this study to identify lens or patient characteristics associated with these effects. Although generalization to the population of conclusions based on associations identified using a small sample should be treated with caution, results from this analysis suggest that lens-induced effects on the cornea may be minimized by fitting lenses that are thinner and more mobile, and by encouraging more frequent lens removal and replacement. Patients with thinner corneas and with high endothelial cell density and low polymegathism before commencing lens wear tended to show fewer effects from extended lens wear.

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5 citations in Scopus
4 citations in Web of Science®
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ID Code: 3355
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal's website (see link) or contact the author. Author contact details:
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Keywords: Contact Lenses, Extended, Wear/, adverse effects, Contact Lenses, Hydrophilic/, adverse effects, Cornea/, physiopathology, Cell Count, Cornea/metabolism, Cornea/pathology, Corneal Diseases/etiology, Corneal Stroma/pathology, Cysts/etiology, Endothelium, Corneal/pathology, Humans, Oxygen/metabolism, Regression Analysis, Research Support, Non, U, S, Gov't, Retrospective Studies
ISSN: 0093-7002
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1987 Lippincott, Williams and Wilkins
Deposited On: 17 Feb 2006 00:00
Last Modified: 10 Aug 2011 17:43

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