Dehydration of hydrogen contact lenses in vitro and in vivo

Efron, Nathan & Young, Graeme (1988) Dehydration of hydrogen contact lenses in vitro and in vivo. Ophthalmic and Physiological Optics, 8(3), pp. 253-256.


An attempt was made to derive a model for predicting the extent of hydrogel lens dehydration in vivo (delta Wv) by using a contact lens refractometer to (1) measure the water content (W) of eight lenses ranging from 36.5 to 85.8% water before and after 90 min lens wear by six subjects; and (2) measure the rate of dehydration of the same lenses in vitro (delta Wt), in a controlled, randomized, double-masked experiment. A significant correlation was demonstrated between W and the rate of change of delta Wt (the dehydration rate, D), whereby lenses of higher water content dehydrate at a slower rate. No correlation was found between W and delta Wv or between D and delta Wv, thus precluding the development of a predictive model. Possible reasons for this failure, and directions for further research, are discussed.

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ID Code: 3360
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details:
Additional URLs:
Keywords: Contact Lenses, Hydrophilic, Desiccation, Adult, Double, Blind Method, Female, Humans, Male, Models, Theoretical, Random Allocation, Refractometry, Research Support, Non, U, S, Gov't
ISSN: 0275-5408
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1988 Blackwell Publishing
Deposited On: 17 Feb 2006 00:00
Last Modified: 15 Jan 2009 06:56

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