Ocular response to hydrogen peroxide

Paugh, Jerry R., Brennan, Noel A., & Efron, Nathan (1988) Ocular response to hydrogen peroxide. American journal of optometry and physiological optics, 65(2), pp. 91-98.


A controlled, randomized, double-masked study was conducted on eight human subjects to determine the threshold level of hydrogen peroxide, which is toxic when introduced into the eye via a high water content (75%; Durasoft 4) hydrogel contact lens. Subjective comfort, conjunctival hyperemia, corneal and conjunctival epithelial staining, and corneal oxygen uptake were assessed in response to 5-min wear of lenses that were presoaked in isotonic saline solutions of physiologic pH containing 0, 25, 50, 100, 200, 400, and 800 parts per million (ppm) hydrogen peroxide. Higher levels of hydrogen peroxide were associated with greater discomfort (p less than 0.05) and increased conjunctival hyperemia (p less than 0.001). The highest level of hydrogen peroxide tested (800 ppm) did not induce significant corneal or conjunctival epithelial staining or alter the corneal aerobic response. We conclude that residual concentrations of hydrogen peroxide in contact lens care systems should not exceed 100 ppm. Practitioners can use these data to estimate the level of residual hydrogen peroxide to which a patient may have been exposed upon lens application after neutralization.

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33 citations in Scopus
19 citations in Web of Science®
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ID Code: 3362
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: n.efron@qut.edu.au
Additional URLs:
Keywords: Eye/, drug effects, Hydrogen Peroxide/, pharmacology, Adult, Conjunctiva/blood supply, Conjunctiva/pathology, Contact Lenses, Cornea/metabolism, Eye/pathology, Female, Humans, Hydrogel, Hyperemia/chemically induced, Male, Osmolar Concentration, Oxygen Consumption, Pain/chemically induced, Polyethylene Glycols, Research Support, Non, U, S, Gov't, Solutions, Staining and Labeling
ISSN: 0093-7002
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1988 Lippincott, Williams and Wilkins
Deposited On: 17 Feb 2006 00:00
Last Modified: 10 Aug 2011 13:21

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