Soft lens lubricants and prelens tear film stability

Golding, Timothy R., Efron, Nathan, & Brennan, Noel A. (1990) Soft lens lubricants and prelens tear film stability. Optometry and Vision Science, 67(6), pp. 461-465.


Soft contact lens wearers complaining of "dry eye" are frequently prescribed rewetting drops, although the mode of action and efficacy of this treatment have not been established. Enhancement of prelens tear film (PLTF) stability could provide a basis for symptomatic relief with solution instillation. Thirty symptomatic hydroxyethyl methacrylate (HEMA) lens wearers participated in 4 separate trials of no solution (baseline), saline, and 2 soft lens lubricants. Solutions were applied for a 6-h adaptation period, and PLTF noninvasive break-up time (NIBUT) was monitored for 1 h after a final instillation. PLTF NIBUT was significantly elevated 1 min after instillation of all solutions (p less than 0.001, logrank test) but this effect persisted for less than 5 min. The transient enhancement of PLTF stability arising from the instillation of these rewetting solutions is unlikely to provide a basis for prolonged symptomatic relief

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17 citations in Web of Science®
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ID Code: 3369
Item Type: Journal Article
Refereed: Yes
Additional Information: Self-archiving of the author-version is not yet supported by this publisher.
For more information, please refer to the journal’s website (see hypertext link) or contact the author.
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Keywords: Contact Lenses, Hydrophilic/, adverse effects, Dry Eye Syndromes/, etiology, Ophthalmic Solutions/, therapeutic use, Tears/, drug effects, Adolescent, Adult, Comparative Study, Dry Eye Syndromes/drug therapy, Female, Humans, Lubrication, Male, Methacrylates, Questionnaires, Research Support, Non, U, S, Gov't
ISSN: 1040-5488
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1990 Lippincott, Williams and Wilkins
Deposited On: 17 Feb 2006 00:00
Last Modified: 10 Aug 2011 13:21

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