Distribution of oxygen across the surface of the human cornea during soft contact lens wear
PURPOSE: To determine whether tear mixing occurs beneath soft contact lenses, we examined the effect of blinking on the oxygen distribution across the corneal surface beneath a nonuniform thickness lens. METHODS: A custom-designed twin polarographic oxygen sensor assembly was used to simultaneously measure the equivalent oxygen percentage (EOP) at central and peripheral corneal locations of 10 human subjects beneath a -6.00 D thin-design hydroxyethyl mathacrylate (HEMA) lens. A -0.25 D lens served as a control. Each lens was worn for 5 min under static (no blinking) and dynamic (12 and 60 blinks/min) conditions. RESULTS: A significantly greater EOP (p = 0.006) was observed at the central (vs. peripheral) cornea during static and dynamic lens wear; central and peripheral oxygenation were unaffected by blinking. CONCLUSIONS: Tear mixing is insignificant beneath thin-design HEMA lenses; therefore, oxygenation across the corneal surface beneath such lenses is best predicted from the lens thickness profile rather than average thickness.
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|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: email@example.com|
|Keywords:||Contact Lenses, Hydrophilic, Cornea/, metabolism, Oxygen/, metabolism, Adolescent, Adult, Biosensing Techniques, Blinking, Female, Humans, Male, Oxygen Consumption, Polarography, Research Support, Non, U, S, Gov't, Tears/metabolism|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 1996 Lippincott Williams & Wilkins|
|Deposited On:||10 Feb 2006|
|Last Modified:||15 Jan 2009 06:57|
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