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Polymersomes, smaller than you think : ferrocene as a TEM probe to determine core structure

Johnston, A. H., Dalton, P. D., & Newman, T. A. (2010) Polymersomes, smaller than you think : ferrocene as a TEM probe to determine core structure. Journal of Nanoparticle Research, 12(6), pp. 1997-2001.

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Abstract

By incorporating ferrocene into the hydrophobic membrane of PEG-b-PCL polymersome nanoparticles it is possible to selectively visualize their core using Transmission Electron Microscopy (TEM). Two different sizes of ferrocene-loaded polymersomes with mean hydrodynamic diameters of approximately 40 and 90 nm were prepared. Image analysis of TEM pictures of these polymersomes found that the mean diameter of the core was 4–5 times smaller than the mean hydrodynamic diameter. The values obtained also allow the surface diameter and internal volume of the core to be calculated.

Impact and interest:

5 citations in Scopus
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5 citations in Web of Science®

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ID Code: 34060
Item Type: Journal Article
Keywords: Nanoparticle, Characterization, Pharmacokinetics, Polymersomes, PEG, PCL, TEM, Biomedicine
DOI: 10.1007/s11051-010-9886-5
ISSN: 1388-0764
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > ATOMIC MOLECULAR NUCLEAR PARTICLE AND PLASMA PHYSICS (020200)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > NANOTECHNOLOGY (100700)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > Schools > School of Engineering Systems
Deposited On: 17 Nov 2010 10:05
Last Modified: 01 Mar 2012 00:15

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