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Gender differences in the effect of fish oil on appetite, inflammation and nutritional status in haemodialysis patients

Zabel, Rachel, Ash, Susan, King, Neil A., Naslund, Erik, & Bauer, Judith D. (2010) Gender differences in the effect of fish oil on appetite, inflammation and nutritional status in haemodialysis patients. Journal of Human Nutrition and Dietetics, 23(4), pp. 416-425.

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    Abstract

    Background: Haemodialysis patients show signs of chronic inflammation and reduced appetite, which is associated with a worse clinical status and an increased mortality risk. Fish oil has anti-inflammatory properties and may be useful as a therapeutic treatment. There is limited evidence to indicate the feasibility and efficacy of this intervention in dialysis patients. The present study aimed to compare the effect of 12 weeks of supplementation with fish oil on markers of appetite and inflammation in male and female haemodialysis patients.

    Methods: The study was conducted in 28 haemodialysis patients. All patients were prescribed 3 g of fish oil per day for 12 weeks. Changes in appetite, plasma fatty acid profiles and inflammatory markers were measured at baseline and at 12 weeks.

    Results: The mean (SD) increase in percent plasma eicosapentaenoic acid was statistically significant [1.1 (0.8) to 4.1 (2.2), P < 0.001], which was a strong indicator of good adherence. There were trends towards reductions in peptide YY (−9%; P = 0.078) and an increase in subjective sensations of hunger (+12%; P = 0.406), which reflects an increase in motivation to eat. Males (n = 13) experienced a more marked increase in hunger compared to females (+23% versus −6%), which was associated with maintenance in C-reactive protein and interleukin-6, and a reduction in soluble intercellular adhesion molecule-1.

    Conclusions: The results obtained demonstrate meaningful trends towards improvements in subjective appetite and certain inflammatory markers (although no change in dietary intake) and this effect was more pronounced in males. However, the levels of some inflammatory markers increased in females and this requires further study. The high level of adherence achieved indicates that an intervention requiring patients to consume four fish oil capsules per day is achievable. This was a short-term study and the effects need to be confirmed in a randomised controlled trial.

    Impact and interest:

    5 citations in Scopus
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    3 citations in Web of Science®

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    ID Code: 34253
    Item Type: Journal Article
    Keywords: Appetite, Fish Oil, Haemodialysis, Inflammation
    DOI: 10.1111/j.1365-277X.2010.01064.x
    ISSN: 0952-3871
    Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NUTRITION AND DIETETICS (111100)
    Divisions: Current > QUT Faculties and Divisions > Faculty of Health
    Current > Institutes > Institute of Health and Biomedical Innovation
    Current > Schools > School of Exercise & Nutrition Sciences
    Current > Schools > School of Public Health & Social Work
    Copyright Owner: © 2010 The Authors. Journal compilation © 2010 The British Dietetic Association Ltd
    Deposited On: 27 Aug 2010 13:29
    Last Modified: 05 Mar 2012 01:31

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