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Development of a multi-scale finite element model of the osteoporotic lumbar vertebral body for the investigation of apparent level vertebra mechanics and micro-level trabecular mechanics.

McDonald, Katrina A., Little, J. Paige, Pearcy, Mark J., & Adam, Clayton J. (2010) Development of a multi-scale finite element model of the osteoporotic lumbar vertebral body for the investigation of apparent level vertebra mechanics and micro-level trabecular mechanics. Medical Engineering & Physics, 32(6), pp. 653-661.

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Abstract

Osteoporotic spinal fractures are a major concern in ageing Western societies. This study develops a multi-scale finite element (FE) model of the osteoporotic lumbar vertebral body to study the mechanics of vertebral compression fracture at both the apparent (whole vertebral body) and micro-structural (internal trabecular bone core)levels. Model predictions were verified against experimental data, and found to provide a reasonably good representation of the mechanics of the osteoporotic vertebral body. This novel modelling methodology will allow detailed investigation of how trabecular bone loss in osteoporosis affects vertebral stiffness and strength in the lumbar spine.

Impact and interest:

13 citations in Scopus
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8 citations in Web of Science®

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475 since deposited on 07 Sep 2010
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ID Code: 34362
Item Type: Journal Article
Keywords: Finite Element, vertebral mechanics, osteoporosis, trabecular mechanics, multi-scale model, vertebral compression fracture
DOI: 10.1016/j.medengphy.2010.04.006
ISSN: 1350-4533
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 IPEM Published by Elsevier Ltd.
Deposited On: 07 Sep 2010 11:29
Last Modified: 01 Mar 2012 00:16

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