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Clonal characterization of bone marrow derived stem cells and their application for bone regeneration

Xiao, Yin, Mareddy, Shobha R., & Crawford, Ross W. (2010) Clonal characterization of bone marrow derived stem cells and their application for bone regeneration. International Journal of Oral Science, 2(3), pp. 127-135.

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Abstract

Tissue engineering allows the design of functionally active cells within supportive bio-scaffolds to promote the development of new tissues such as cartilage and bone for the restoration of pathologically altered tissues. However, all bone tissue engineering applications are limited by a shortage of stem cells. The adult bone marrow stroma contains a subset of nonhematopoietic cells referred to as bone marrow mesenchymal stem cells (BMSCs). BMSCs are of interest because they are easily isolated from a small aspirate of bone marrow and readily generate single- cell-derived colonies. These cells have the capacity to undergo extensive replication in an undifferentiated state ex vivo. In addition, BMSCs have the potential to develop either in vitro or in vivo into distinct mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Thus, BMSCs are an attractive cell source for tissue engineering approaches. However, BMSCs are not homo- geneous and the quantity of stem cells decreases in the bone marrow in aged population. A sequential loss of lineage differentiation potential has been found in the mixed culture of bone marrow stromal cells due to a heterogenous popu- lation. Therefore, a number of studies have proposed that homogenous bone marrow stem cells can be generated from clonal culture of bone marrow cells and that BMSC clones have the greatest potential for the application of bone regeneration in vivo

Impact and interest:

20 citations in Scopus
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18 citations in Web of Science®

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ID Code: 37603
Item Type: Journal Article
Additional URLs:
Keywords: bone morrow, stem cell, mesenchymal, clonal culture, regenerative medicine, differentiation
DOI: 10.4248/IJOS10045
ISSN: 1674-2818
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2010 Sichuan University Press
Copyright Statement: The articles published in this journal are protected by copyright, which covers translation rights and the exclusive right to reproduce and distribute all of the articles printed in the journal. No material published in the journal may be stored on microfilm or videocassettes or in an electronic database or the like, or reproduced photographically, without the prior written permission of the publisher.
Deposited On: 30 Sep 2010 07:55
Last Modified: 31 May 2011 00:58

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