Central and peripheral oxygen transmissibility thresholds to avoid corneal swelling during open eye soft contact lens wear

Morgan, Philip B., Brennan, Noel A., Maldonado-Codina, Carole, Quhill, Walead, Rashid, Khaled, & Efron, Nathan (2009) Central and peripheral oxygen transmissibility thresholds to avoid corneal swelling during open eye soft contact lens wear. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 92(B), pp. 361-365.

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This study was designed to derive central and peripheral oxygen transmissibility (Dk/t) thresholds for soft contact lenses to avoid hypoxia-induced corneal swelling (increased corneal thickness) during open eye wear. Central and peripheral corneal thicknesses were measured in a masked and randomized fashion for the left eye of each of seven subjects before and after 3 h of afternoon wear of five conventional hydrogel and silicone hydrogel contact lens types offering a range of Dk/t from 2.4 units to 115.3 units. Curve fitting for plots of change in corneal thickness versus central and peripheral Dk/t found threshold values of 19.8 and 32.6 units to avoid corneal swelling during open eye contact lens wear for a typical wearer. Although some conventional hydrogel soft lenses are able to achieve this criterion for either central or peripheral lens areas (depending on lens power), in general, no conventional hydrogel soft lenses meet both the central and peripheral thresholds. Silicone hydrogel contact lenses typically meet both the central and peripheral thresholds and use of these lenses therefore avoids swelling in all regions of the cornea. ' 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 92B: 361–365, 2010

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11 citations in Scopus
8 citations in Web of Science®
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ID Code: 37676
Item Type: Journal Article
Refereed: Yes
Keywords: contact lens, oxygen transmissibility, corneal swelling, hydrogel, silicone hydrogel
DOI: 10.1002/jbm.b.31522
ISSN: 1552-4973
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Deposited On: 04 Oct 2010 00:35
Last Modified: 29 Feb 2012 14:14

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