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Diffusion tensor of water in model articular cartilage

Momot, Konstantin I. (2011) Diffusion tensor of water in model articular cartilage. European Biophysics Journal, 40(1), pp. 81-91.

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Abstract

We used Monte Carlo simulations of Brownian dynamics of water to study anisotropic water diffusion in an idealised model of articular cartilage. The main aim was to use the simulations as a tool for translation of the fractional anisotropy of the water diffusion tensor in cartilage into quantitative characteristics of its collagen fibre network. The key finding was a linear empirical relationship between the collagen volume fraction and the fractional anisotropy of the diffusion tensor. Fractional anisotropy of the diffusion tensor is potentially a robust indicator of the microstructure of the tissue because, in the first approximation, it is invariant to the inclusion of proteoglycans or chemical exchange between free and collagen-bound water in the model. We discuss potential applications of Monte Carlo diffusion-tensor simulations for quantitative biophysical interpretation of MRI diffusion-tensor images of cartilage. Extension of the model to include collagen fibre disorder is also discussed.

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4 citations in Scopus
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3 citations in Web of Science®

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168 since deposited on 04 Oct 2010
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ID Code: 37681
Item Type: Journal Article
Additional URLs:
Keywords: diffusion tensor imaging, articular cartilage, magnetic resonance, Monte Carlo
DOI: 10.1007/s00249-010-0629-4
ISSN: 0175-7571
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Physics
Copyright Owner: Copyright 2010 Springer-Verlag
Deposited On: 04 Oct 2010 10:29
Last Modified: 23 Oct 2013 14:02

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