Diffusion tensor of water in model articular cartilage

Momot, Konstantin I. (2011) Diffusion tensor of water in model articular cartilage. European Biophysics Journal, 40(1), pp. 81-91.

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We used Monte Carlo simulations of Brownian dynamics of water to study anisotropic water diffusion in an idealised model of articular cartilage. The main aim was to use the simulations as a tool for translation of the fractional anisotropy of the water diffusion tensor in cartilage into quantitative characteristics of its collagen fibre network. The key finding was a linear empirical relationship between the collagen volume fraction and the fractional anisotropy of the diffusion tensor. Fractional anisotropy of the diffusion tensor is potentially a robust indicator of the microstructure of the tissue because, in the first approximation, it is invariant to the inclusion of proteoglycans or chemical exchange between free and collagen-bound water in the model. We discuss potential applications of Monte Carlo diffusion-tensor simulations for quantitative biophysical interpretation of MRI diffusion-tensor images of cartilage. Extension of the model to include collagen fibre disorder is also discussed.

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9 citations in Scopus
8 citations in Web of Science®
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203 since deposited on 04 Oct 2010
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ID Code: 37681
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: diffusion tensor imaging, articular cartilage, magnetic resonance, Monte Carlo
DOI: 10.1007/s00249-010-0629-4
ISSN: 0175-7571
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2010 Springer-Verlag
Deposited On: 04 Oct 2010 00:29
Last Modified: 23 Oct 2013 04:02

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