Diffusion tensor of water in model articular cartilage
Momot, Konstantin I. (2010) Diffusion tensor of water in model articular cartilage. European Biophysics Journal, 40, pp. 81-91. (In Press)
We used Monte Carlo simulations of Brownian dynamics of water to study anisotropic water diffusion in an idealised model of articular cartilage. The main aim was to use the simulations as a tool for translation of the fractional anisotropy of the water diffusion tensor in cartilage into quantitative characteristics of its collagen fibre network. The key finding was a linear empirical relationship between the collagen volume fraction and the fractional anisotropy of the diffusion tensor. Fractional anisotropy of the diffusion tensor is potentially a robust indicator of the microstructure of the tissue because, in the first approximation, it is invariant to the inclusion of proteoglycans or chemical exchange between free and collagen-bound water in the model. We discuss potential applications of Monte Carlo diffusion-tensor simulations for quantitative biophysical interpretation of MRI diffusion-tensor images of cartilage. Extension of the model to include collagen fibre disorder is also discussed.
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|Item Type:||Journal Article|
|Keywords:||diffusion tensor imaging, articular cartilage, magnetic resonance, Monte Carlo|
|Subjects:||Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
Past > Schools > Physics
|Copyright Owner:||Copyright 2010 Springer-Verlag|
|Deposited On:||04 Oct 2010 10:29|
|Last Modified:||29 Feb 2012 20:32|
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