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Cell interactions of osteoarthritic subchondral bone osteoblasts and articular chondrocytes aggravate MMP-2 and MMP-9 production through the mediation of ERK1/2 and JNK phosphorylation

Prasadam, Indira, Crawford, Ross W., & Xiao, Yin (2010) Cell interactions of osteoarthritic subchondral bone osteoblasts and articular chondrocytes aggravate MMP-2 and MMP-9 production through the mediation of ERK1/2 and JNK phosphorylation. In European Cells and Materials, AO Research Institute Davos , Davos Congress Centre, Davos, Switzerland, p. 7.

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    Abstract

    Matrix Metalloproteinases (MMP) play a key role in osteoarthritis (OA) development. The aim of the present study was to investigate whether, the cross-talk between subchondral bone osteoblasts (SBOs) and articular cartilage chondrocytes (ACCs) in OA alters the expression and regulation of MMPs, and also to test the potential involvement of mitogen activated protein kinase (MAPK) signalling pathway during this process.

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    ID Code: 38164
    Item Type: Conference Paper
    Additional URLs:
    Keywords: cell interaction, Osteoathritis, MMP-2, MMP-9, ERK 1/2, Osteoblast, Articular chondrocyte
    ISSN: 1473-2262
    Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
    Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
    Current > Institutes > Institute of Health and Biomedical Innovation
    Past > Schools > School of Engineering Systems
    Copyright Owner: Copyright 2010 [please consult the authors]
    Deposited On: 26 Oct 2010 07:30
    Last Modified: 09 Jun 2011 00:59

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