New drugs for the treatment of coronary artery syndromes

Doggrell, Sheila (2010) New drugs for the treatment of coronary artery syndromes. Expert Opinion on Pharmacotherapy, 11(2), pp. 325-329.

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Background: Acute coronary syndromes are a major cause of mortality and morbidity. Objectives/Methods: The objective of this evaluation is to review the clinical trials of two new drugs being developed for the treatment of acute coronary syndromes. The first drug is the anti-coagulant otamixaban, and the trial compared otamixaban with unfractionated heparin and eptifibatide in acute coronary syndromes. The second drug is the anti-platelet ticagrelor, and the trial compared ticagrelor with clopidogrel in acute coronary syndromes. Results: In the SEPIA-ACS1 TIMI 42 trial, the primary efficacy endpoint occurred in 6.2% of subjects treated with unfractionated heparin and eptifibatide, and to a significantly lesser extent with otamixaban. In the PLATO trial, the primary efficacy endpoint had occurred less in the ticagrelor group (9.8%) than in the clopidogrel group (11.7%) at 12 months. Conclusions: Two new drugs for acute coronary syndromes, otamixaban and ticagrelor, have recently been shown to have benefits in subjects undergoing percutaneous interventions compared to the present standard regimens for this condition.

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ID Code: 38305
Item Type: Journal Article
Refereed: No
Keywords: acute coronary syndromes, clinical trials, otamixaban, ticagrelor
DOI: 10.1517/14656560903473173
ISSN: 1465-6566
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Medical Sciences
Copyright Owner: Copyright 2010 Informa UK Ltd
Deposited On: 03 Nov 2010 03:15
Last Modified: 19 Jan 2012 05:34

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