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The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers

Doggrell, Sheila Anne (2010) The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers. Expert Opinion on Investigational Drugs, 19(3), pp. 451-454.

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Abstract

Background: The hedgehog signaling pathway is vital in early development, but then becomes dormant, except in some cancer tumours. Hedgehog inhibitors are being developed for potential use in cancer. Objectives/Methods: The objective of this evaluation is to review the initial clinical studies of the hedgehog inhibitor, GDC-0449, in subjects with cancer. Results: Phase I trials have shown that GDC-0449 has benefits in subjects with metastatic or locally advanced basal-cell carcinoma and in one subjects with medulloblastoma. GDC-0449 was well tolerated. Conclusions: Long term efficacy and safety studies of GDC-0449 in these conditions and other solid cancers are now underway. These clinical trials with GDC-0449, and trials with other hedgehog inhibitors, will reveal whether it is beneficial and safe to inhibit the hedgehog pathway, in a wide range of solid tumours or not.

Impact and interest:

9 citations in Scopus
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8 citations in Web of Science®

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ID Code: 38308
Item Type: Journal Article
Keywords: basal-cell carcinoma, , GDC-0449, , hedgehog inhibitors, , medulloblastoma
DOI: 10.1517/13543780903571649
ISSN: 1354-3784
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Basic Pharmacology (111501)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Medical Sciences
Copyright Owner: Copyright 2010 Informa UK Ltd
Deposited On: 03 Nov 2010 11:51
Last Modified: 19 Jan 2012 15:33

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