Oral fingolimod for relapsing-remitting multiple sclerosis

Doggrell, Sheila Anne (2010) Oral fingolimod for relapsing-remitting multiple sclerosis. Expert Opinion on Pharmacotherapy, 11(10), pp. 1777-1781.

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Background: Most people with multiple sclerosis have the relapsing-remitting type.

Objective/methods: The objective was to evaluate two clinical trials of fingolimod in relapsing multiple sclerosis.

Results: FREEDOMS (FTY720 Research Evaluation Effects of Daily Oral therapy in Multiple Sclerosis), a Phase III placebo-controlled trial, showed that fingolimod (0.5 or 1.25 mg) reduced the relapse rate and disability in multiple sclerosis, compared to placebo. Fingolimod (0.5 or 1.25 mg) has been compared to interferon β-1a in a Phase III clinical trial (TRANSFORMS; Trial Assessing Injectable Interferon versus FTY720 Oral in Relapsing-Remitting Multiple Sclerosis) and shown to be more efficacious than interferon β-1a in reducing relapse rates. However, fingolimod did increase the risk of infections and skin cancers.

Conclusions: Only the lower dose of fingolimod (0.5 mg), which possibly has less toxicity, should be considered for prevention of relapses in relapsing-remitting multiple sclerosis.

Impact and interest:

6 citations in Scopus
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3 citations in Web of Science®

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Full-text downloads:

21 since deposited on 03 Nov 2010
1 in the past twelve months

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ID Code: 38311
Item Type: Journal Article
Refereed: Yes
Keywords: fingolimod, interferon β-1a, multiple sclerosis
DOI: 10.1517/14656566.2010.481671
ISSN: 1465-6566
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Medical Sciences
Copyright Owner: Copyright 2010 Informa Healthcare
Deposited On: 03 Nov 2010 04:03
Last Modified: 25 Mar 2015 02:59

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