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Does the p38 MAP kinase inhibitor pamapimod have potential for the treatment of rheumatoid arthritis?

Doggrell, Sheila Anne & Christensen, Anne-Marie (2010) Does the p38 MAP kinase inhibitor pamapimod have potential for the treatment of rheumatoid arthritis? Expert Opinion on Pharmacotherapy, 11(14), pp. 2437-2442.

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Abstract

Background: Methotrexate alone or in combination with other agents is the standard treatment for moderate-to-severe rheumatoid arthritis. As the biological agents are expensive, they are not usually used until methotrexate has failed to give a good response. Thus, there is scope for the development of cheaper drugs that can be used instead of methotrexate or in addition to methotrexate.

Objectives/methods: Pamapimod is a p38α inhibitor being developed for use in the treatment of rheumatoid arthritis. The objective was to evaluate the recent clinical trials of pamapimod in subjects with rheumatoid arthritis.

Results: There is no clear cut evidence that pamapimod alone or in the presence of methotrexate is efficacious in subjects with rheumatoid arthritis, but it does cause adverse effects. Conclusion: It is unlikely that pamapimod will be useful in the treatment of rheumatoid arthritis.

Impact and interest:

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ID Code: 38312
Item Type: Journal Article
Keywords: pamapimod, methotrexate, p38α inhibition, rheumatoid arthritis, pharmacokinetics
DOI: 10.1517/14656566.2010.507631
ISSN: 1465-6566
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Medical Sciences
Copyright Owner: Copyright 2010 Informa Healthcare
Deposited On: 03 Nov 2010 13:53
Last Modified: 19 Jan 2012 15:34

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