Resolvin inflammation with pain

Doggrell, Sheila Anne (2010) Resolvin inflammation with pain. Expert Opinion on Investigational Drugs, 19(11), pp. 1461-1464.

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Background: Inflammation and pain coexist in conditions such as arthritis, inflammatory bowel disease, and lower back pain. The drugs currently used to treat the combination of inflammation and pain all have disadvantages. Thus, new drugs and new approaches are needed to treat inflammation with pain. The resolvins are considered to be part of the natural resolving mechanism for inflammation, and have been shown to prevent inflammation in animal models. Objectives/methods: To evaluate a paper suggesting that the resolvins RvE1 and RvD1 attenuate inflammatory pain in animal models.

Results: RvE1 has been shown to attenuate inflammation and, to a lesser extent, pain in animal models. Limited results are presented of the effectiveness of RvD1 against inflammatory pain. Conclusion: Drugs that mimic or potentiate the effects of the resolvins may be useful for the treatment of some inflammation with pain.

Impact and interest:

1 citations in Scopus
1 citations in Web of Science®
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129 since deposited on 03 Nov 2010
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ID Code: 38313
Item Type: Journal Article
Refereed: Yes
Keywords: inflammation, pain, resolvins
DOI: 10.1517/13543784.2010.527946
ISSN: 1354-3784
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Basic Pharmacology (111501)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Medical Sciences
Copyright Owner: Copyright 2010 Informa Healthcare
Deposited On: 03 Nov 2010 03:00
Last Modified: 19 Jan 2012 05:32

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