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Exploring retinal and functional markers of diabetic neuropathy

Moavenshahidi, Ayda, Sampson, Geoff, Pritchard, Nicola, Edwards, Katie P., Russell, Anthony, Malik, Rayaz A., & Efron, Nathan (2010) Exploring retinal and functional markers of diabetic neuropathy. Clinical and Experimental Optometry, 93(5), pp. 309-323.

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      Abstract

      Diabetic peripheral neuropathy (DPN) is one of the most debilitating complications of diabetes. DPN is a major cause of foot ulceration and lower limb amputation. Early diagnosis and management is a key factor in reducing morbidity and mortality. Current techniques for clinical assessment of DPN are relatively insensitive for detecting early disease or involve invasive procedures such as skin biopsies. There is a need for less painful, non-invasive and safe evaluation methods. Eye care professionals already play an important role in the management of diabetic retinopathy; however recent studies have indicated that the eye may also be an important site for the diagnosis and monitoring of neuropathy. Corneal nerve morphology has been shown to be a promising marker of diabetic neuropathy occurring elsewhere in the body, and emerging evidence tentatively suggests that retinal anatomical markers and a range of functional visual indicators could similarly provide useful information regarding neural damage in diabetes – although this line of research is, as yet, less well established. This review outlines the growing body of evidence supporting a potential diagnostic role for retinal structure and visual functional markers in the diagnosis and monitoring of peripheral neuropathy in diabetes.

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      5 citations in Scopus
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      3 citations in Web of Science®

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      ID Code: 38384
      Item Type: Journal Article
      Keywords: Diabetes Mellitus, Optical Coherence Tomography, Peripheral Neuropathy, Retina, Visual Fields, Visual Function
      DOI: 10.1111/j.1444-0938.2010.00491.x
      ISSN: 0816-4622
      Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
      Divisions: Current > QUT Faculties and Divisions > Faculty of Health
      Current > Institutes > Institute of Health and Biomedical Innovation
      Current > Schools > School of Optometry & Vision Science
      Copyright Owner: Copyright 2010 Wiley-Blackwell Publishing Ltd.
      Deposited On: 10 Nov 2010 11:26
      Last Modified: 11 Aug 2011 01:53

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