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Mild systemic hypoxia and photopic visual field sensitivity

Feigl, Beatrix, Zele, Andrew J., & Stewart, Ian B. (2010) Mild systemic hypoxia and photopic visual field sensitivity. Acta Ophthalmologica.

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    Abstract

    Purpose: Flickering stimuli increase the metabolic demand of the retina,making it a sensitive perimetric stimulus to the early onset of retinal disease. We determine whether flickering stimuli are a sensitive indicator of vision deficits resulting from to acute, mild systemic hypoxia when compared to standard static perimetry. Methods: Static and flicker visual perimetry were performed in 14 healthy young participants while breathing 12% oxygen (hypoxia) under photopic illumination. The hypoxia visual field data were compared with the field data measured during normoxia. Absolute sensitivities (in dB) were analysed in seven concentric rings at 1°, 3°, 6°, 10°, 15°, 22° and 30° eccentricities as well as mean defect (MD) and pattern defect (PD) were calculated. Preliminary data are reported for mesopic light levels. Results: Under photopic illumination, flicker and static visual field sensitivities at all eccentricities were not significantly different between hypoxia and normoxia conditions. The mean defect and pattern defect were not significantly different for either test between the two oxygenation conditions. Conclusion: Although flicker stimulation increases cellular metabolism, flicker photopic visual field impairment is not detected during mild hypoxia. These findings contrast with electrophysiological flicker tests in young participants that show impairment at photopic illumination during the same levels of mild hypoxia. Potential mechanisms contributing to the difference between the visual fields and electrophysiological flicker tests including variability in perimetric data, neuronal adaptation and vascular autoregulation, are considered. The data have implications for the use of visual perimetry in the detection of ischaemic/hypoxic retinal disorders under photopic and mesopic light levels.

    Impact and interest:

    3 citations in Scopus
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    0 citations in Web of Science®

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    ID Code: 38466
    Item Type: Journal Article
    Keywords: Flicker, hypoxia, Perimetry, static
    DOI: 10.1111/j.1755-3768.2010.01959.x
    ISSN: 1755-375X
    Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optometry and Ophthalmology not elsewhere classified (111399)
    Divisions: Current > QUT Faculties and Divisions > Faculty of Health
    Current > Institutes > Institute of Health and Biomedical Innovation
    Current > Schools > School of Exercise & Nutrition Sciences
    Current > Schools > School of Optometry & Vision Science
    Funding:
    • ARC DISCOVERY GRANT/DP1096354
    Copyright Owner: Copyright 2010 The Authors. Journal compilation © 2010 Acta Ophthalmologica
    Deposited On: 15 Nov 2010 07:47
    Last Modified: 08 Jul 2014 13:40

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