Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm

Markwell, Emma L., Feigl, Beatrix, & Zele, Andrew J. (2010) Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm. Clinical and Experimental Optometry, 93(3), pp. 137-147.

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Recently discovered intrinsically photosensitive melanopsin retinal ganglion cells contribute to the maintenance of pupil diameter, recovery and post-illumination components of the pupillary light reflex and provide the primary environmental light input to the suprachiasmatic nucleus for photoentrainment of the circadian rhythm. This review summarises recent progress in understanding intrinsically photosensitive ganglion cell histology and physiological properties in the context of their contribution to the pupillary and circadian functions and introduces a clinical framework for using the pupillary light reflex to evaluate inner retinal (intrinsically photosensitive melanopsin ganglion cell) and outer retinal (rod and cone photoreceptor) function in the detection of retinal eye disease.

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34 citations in Scopus
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33 citations in Web of Science®

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ID Code: 38515
Item Type: Journal Article
Refereed: Yes
Keywords: Circadian Rhythm, Melanopsin, Pupillary reflex, Retinal Disease, Retinal Ganglion Cells, retinal photorecpetors
DOI: 10.1111/j.1444-0938.2010.00479.x
ISSN: 0816-4622
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: © 2010 The Authors. Journal compilation © 2010 Optometrists Association Australia
Deposited On: 22 Nov 2010 22:02
Last Modified: 12 Nov 2012 22:33

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