Effect of surgical approach on bone vascularisation, fracture and soft tissue healing : comparison of less invasive to open approach

Wullschleger, Martin Eduard (2010) Effect of surgical approach on bone vascularisation, fracture and soft tissue healing : comparison of less invasive to open approach. PhD thesis, Queensland University of Technology.


Over the past ten years, minimally invasive plate osteosynthesis (MIPO) for the fixation of long bone fractures has become a clinically accepted method with good outcomes, when compared to the conventional open surgical approach (open reduction internal fixation, ORIF). However, while MIPO offers some advantages over ORIF, it also has some significant drawbacks, such as a more demanding surgical technique and increased radiation exposure. No clinical or experimental study to date has shown a difference between the healing outcomes in fractures treated with the two surgical approaches. Therefore, a novel, standardised severe trauma model in sheep has been developed and validated in this project to examine the effect of the two surgical approaches on soft tissue and fracture healing. Twenty four sheep were subjected to severe soft tissue damage and a complex distal femur fracture. The fractures were initially stabilised with an external fixator. After five days of soft tissue recovery, internal fixation with a plate was applied, randomised to either MIPO or ORIF. Within the first fourteen days, the soft tissue damage was monitored locally with a compartment pressure sensor and systemically by blood tests. The fracture progress was assessed fortnightly by x-rays. The sheep were sacrificed in two groups after four and eight weeks, and CT scans and mechanical testing performed. Soft tissue monitoring showed significantly higher postoperative Creatine Kinase and Lactate Dehydrogenase values in the ORIF group compared to MIPO. After four weeks, the torsional stiffness was significantly higher in the MIPO group (p=0.018) compared to the ORIF group. The torsional strength also showed increased values for the MIPO technique (p=0.11). The measured total mineralised callus volumes were slightly higher in the ORIF group. However, a newly developed morphological callus bridging score showed significantly higher values for the MIPO technique (p=0.007), with a high correlation to the mechanical properties (R2=0.79). After eight weeks, the same trends continued, but without statistical significance. In summary, this clinically relevant study, using the newly developed severe trauma model in sheep, clearly demonstrates that the minimally invasive technique minimises additional soft tissue damage and improves fracture healing in the early stage compared to the open surgical approach method.

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ID Code: 38523
Item Type: QUT Thesis (PhD)
Supervisor: Schuetz, Michael, Pearcy, Mark, & Steck, Roland
Keywords: animal model, fracture healing, internal fixator, minimally invasive osteosynthesis, minimally invasive plate osteosynthesis, multi-fragmentary fracture, ovine model, percutaneous plating, plate osteosynthesis, soft tissue trauma, trauma model
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Institution: Queensland University of Technology
Deposited On: 15 Nov 2010 05:38
Last Modified: 22 Jun 2017 14:43

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