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Magnocellular and parvocellular pathway mediated luminance contrast discrimination in amblyopia

Zele, Andrew J., Wood, Joanne M., & Girgenti, Cameron (2010) Magnocellular and parvocellular pathway mediated luminance contrast discrimination in amblyopia. Vision Research, 50(10), pp. 969-976.

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Abstract

To evaluate whether luminance contrast discrimination losses in amblyopia on putative magnocellular (MC) and parvocellular (PC) pathway tasks reflect deficits at retinogeniculate or cortical sites. Fifteen amblyopes including six anisometropes, seven strabismics, two mixed and 12 age-matched controls were investigated. Contrast discrimination was measured using established psychophysical procedures that differentiate MC and PC processing. Data were described with a model of the contrast response of primate retinal ganglion cells. All amblyopes and controls displayed the same contrast signatures on the MC and PC tasks, with three strabismics having reduced sensitivity. Amblyopic PC contrast gain was similar to electrophysiological estimates from visually normal, non-human primates. Sensitivity losses evident in a subset of the amblyopes reflect cortical summation deficits, with no change in retinogeniculate contrast responses. The data do not support the proposal that amblyopic contrast sensitivity losses on MC and PC tasks reflect retinogeniculate deficits, but rather are due to anomalous post-retinogeniculate cortical processing of retinal signals.

Impact and interest:

5 citations in Scopus
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5 citations in Web of Science®

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ID Code: 38525
Item Type: Journal Article
Keywords: Amblyopia, Magnocellular, Parvocellular, Contrast, Retina, Cortex, Strabismus, Anisometropia
DOI: 10.1016/j.visres.2010.03.002
ISSN: 0042-6989
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optometry and Ophthalmology not elsewhere classified (111399)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Funding:
  • ARC DISCOVERY GRANT/DP1096354
Copyright Owner: Copyright 2010 Elsevier
Deposited On: 18 Nov 2010 09:31
Last Modified: 08 Jul 2014 13:42

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