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A poly(D,L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography

Melchels, Ferry P.W., Feijen, Jan, & Grijpma, Dirk W. (2009) A poly(D,L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography. Biomaterials, 30(23-24), pp. 3801-3809.

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Abstract

Porous polylactide constructs were prepared by stereolithography, for the first time without the use of reactive diluents. Star-shaped poly(D,L-lactide) oligomers with 2, 3 and 6 arms were synthesised, end-functionalised with methacryloyl chloride and photocrosslinked in the presence of ethyl lactate as a non-reactive diluent. The molecular weights of the arms of the macromers were 0.2, 0.6, 1.1 and 5 kg/mol, allowing variation of the crosslink density of the resulting networks. Networks prepared from macromers of which the molecular weight per arm was 0.6 kg/mol or higher had good mechanical properties, similar to linear high molecular weight poly(D,L-lactide). A resin based on a 2-armed poly(D,L-lactide) macromer with a molecular weight of 0.6 kg/mol per arm (75 wt%), ethyl lactate (19 wt%), photo-initiator (6 wt%), inhibitor and dye was prepared. Using this resin, films and computer-designed porous constructs were accurately fabricated by stereolithography. Pre-osteoblasts showed good adherence to these photocrosslinked networks. The proliferation rate on these materials was comparable to that on high molecular weight poly(D,L-lactide) and tissue culture polystyrene.

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ID Code: 38846
Item Type: Journal Article
Keywords: Polylactide, Photo-crosslinking, Non-reactive diluent, Rapid prototyping, Stereolithography, Tissue engineering scaffolds
DOI: 10.1016/j.biomaterials.2009.03.055
ISSN: 0142-9612
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2009 Elsevier Ltd All rights reserved.
Deposited On: 24 Nov 2010 14:28
Last Modified: 01 Mar 2012 00:14

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