Mathematically defined tissue engineering scaffold architectures prepared by stereolithography

Melchels, Ferry P.W., Bertoldi, Katia, Gabbrielli, Ruggero, Velders, Aldrik, Feijen, Jan, & Grijpma, Dirk W. (2010) Mathematically defined tissue engineering scaffold architectures prepared by stereolithography. Biomaterials, 31(27), pp. 6909-6916.

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The technologies employed for the preparation of conventional tissue engineering scaffolds restrict the materials choice and the extent to which the architecture can be designed. Here we show the versatility of stereolithography with respect to materials and freedom of design. Porous scaffolds are designed with computer software and built with either a poly(d,l-lactide)-based resin or a poly(d,l-lactide-co-ε-caprolactone)-based resin. Characterisation of the scaffolds by micro-computed tomography shows excellent reproduction of the designs. The mechanical properties are evaluated in compression, and show good agreement with finite element predictions. The mechanical properties of scaffolds can be controlled by the combination of material and scaffold pore architecture. The presented technology and materials enable an accurate preparation of tissue engineering scaffolds with a large freedom of design, and properties ranging from rigid and strong to highly flexible and elastic.

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ID Code: 38851
Item Type: Journal Article
Refereed: Yes
Keywords: rapid prototyping, stereolithography, microstructure, tissue engineering scaffold, three dimensional printing
DOI: 10.1016/j.biomaterials.2010.05.068
ISSN: 0142-9612
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2010 Elsevier Ltd All rights reserved.
Deposited On: 24 Nov 2010 05:29
Last Modified: 29 Feb 2012 14:14

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