Melchels, Ferry, Malda, Jos , Fedorovich, Natalja , Alblas, Jacqueline , & Woodfield, Tim (2011) Organ printing. In Kirkpatrick, James, Hutmacher, Dietmar, Healy, Kevin, Grainger, David, & Ducheyne, Paul (Eds.) Comprehensive Biomaterials [Six-Volumes]. Elsevier Science, Amsterdam ; Boston.
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Organ printing techniques offer the potential to produce living 3D tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these techniques, spatial variations along multiple axes with high geometric complexity can be obtained.. The level of control offered by these technologies to develop printed tissues will allow tissue engineers to better study factors that modulate tissue formation and function, and provide a valuable tool to study the effect of anatomy on graft performance.
In this chapter we discuss the history behind substrate patterning and cell and organ printing, and the rationale for developing organ printing techniques with respect to limitations of current clinical tissue engineering strategies to effectively repair damaged tissues. We discuss current 2-dimensional and 3-dimesional strategies for assembling cells as well as the necessary support materials such as hydrogels, bioinks and natural and synthetic polymers adopted for organ printing research. Furthermore, given the current state-of-the-art in organ printing technologies, we discuss some of their limitations and provide recommendations for future developments in this rapidly growing field.
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|Item Type:||Book Chapter|
|Keywords:||Tissue engineering, Cell printing, Substrate patterning, Vascularization, Tissue architecture, Solid freeform fabrication, Rapid prototyping, Computer aided design, Hydrogel, Inkjet printing, 3D plotting, Robotic dispensing, High throughput, Nutrient|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering|
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
|Copyright Owner:||Copyright 2011 Elsevier Science|
|Deposited On:||24 Nov 2010 16:06|
|Last Modified:||24 Oct 2013 15:39|
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