A review of rapid prototyping techniques for tissue engineering purposes

Peltola, Sanna M., Grijpma, Dirk W., Melchels, Ferry P.W., & Kellomäki, Minna (2008) A review of rapid prototyping techniques for tissue engineering purposes. Annals of Medicine, 40(4), pp. 268-280.

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Rapid prototyping (RP) is a common name for several techniques, which read in data from computer-aided design (CAD) drawings and manufacture automatically threedimensional objects layer-by-layer according to the virtual design. The utilization of RP in tissue engineering enables the production of three-dimensional scaffolds with complex geometries and very fine structures. Adding micro- and nanometer details into the scaffolds improves the mechanical properties of the scaffold and ensures better cell adhesion to the scaffold surface. Thus, tissue engineering constructs can be customized according to the data acquired from the medical scans to match the each patient’s individual needs. In addition RP enables the control of the scaffold porosity making it possible to fabricate applications with desired structural integrity. Unfortunately, every RP process has its own unique disadvantages in building tissue engineering scaffolds. Hence, the future research should be focused into the development of RP machines designed specifically for fabrication of tissue engineering scaffolds, although RP methods already can serve as a link between tissue and engineering.

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269 citations in Scopus
224 citations in Web of Science®
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ID Code: 38860
Item Type: Journal Article
Refereed: Yes
Keywords: 3D Bioplotter®, fused deposition modeling, organ printing, 3D printing, rapid prototyping, scaffold fabrication, selective laser sintering, stereolithography, tissue engineering, two-photon polymerization
DOI: 10.1080/07853890701881788
ISSN: 0785-3890
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2008 Informa UK Ltd.
Deposited On: 24 Nov 2010 06:42
Last Modified: 10 Aug 2011 16:48

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