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Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins

Seck, Tetsu M., Melchels, Ferry P.W., Feijen, Jan, & Grijpma, Dirk W. (2010) Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins. Journal of Controlled Release, 148(1), pp. 34-41.

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Abstract

Designed three-dimensional biodegradable poly(ethylene glycol)/poly(D,L-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photopolymerisable aqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible light photo-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous and non-porous hydrogels with well-defined architectures and good mechanical properties were prepared. Porous hydrogel structures with a gyroid pore network architecture showed narrow pore size distributions, excellent pore interconnectivity and good mechanical properties. The structures showed good cell seeding characteristics, and human mesenchymal stem cells adhered and proliferated well on these materials.

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30 citations in Scopus
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21 citations in Web of Science®

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ID Code: 38862
Item Type: Journal Article
Keywords: Biodegradable hydrogels, designed porous structures, stereolithography, macromer photopolymerisation, tissue engineering
DOI: 10.1016/j.jconrel.2010.07.111
ISSN: 0168-3659
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2010 Elsevier B.V. All rights reserved.
Deposited On: 24 Nov 2010 16:51
Last Modified: 01 Mar 2012 00:23

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