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Fabrication of osteochondral scaffolds with stereolithography

Melchels, F.P.W., Grijpma, D.W., & Feijen, J. (2005) Fabrication of osteochondral scaffolds with stereolithography. In 14th Annual Meeting of the Netherlands Society for Biomaterials and Tissue Engineering, 2005, Lunteren, Netherlands.

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    Abstract

    The osteochondral defect is a classical model for a multiple-tissue problem[1]. Tissue engineering of either bone or cartilage imposes different demands on a scaffold concerning porosity, pore size and interconnectivity. Furthermore, local release of tissue-specific growth factors necessitates a tailored architecture. For the fabrication of an osteochondral scaffold with region specific architecture, an advanced technique is required. Stereolithography is a rapid prototyping technique that allows for the creation of such 3D polymer objects with well-defined architecture. Its working principle is the partial irradiation of a resin, causing a liquid-solid transition. By irradiating this resin by a computer-driven light source, a solid 3D object is constructed layer by layer. To make biodegradable polymers applicable in stereolithography, low-molecular weight polymers have to be functionalised with double bonds to enable photo-initiated crosslinking.

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    ID Code: 38871
    Item Type: Conference Paper
    Keywords: osteochondral defect, tissue engineering, osteochondral scaffold, region-specific architecture
    Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
    Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
    Current > Institutes > Institute of Health and Biomedical Innovation
    Past > Schools > School of Engineering Systems
    Copyright Owner: Copyright 2005 Please consult the authors.
    Deposited On: 25 Nov 2010 12:49
    Last Modified: 04 Jul 2012 10:55

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