Migration of breast cancer cells : understanding the roles of volume exclusion and cell-to-cell adhesion
Simpson, Matthew, Towne, Chris L., McElwain, Sean, & Upton, Zee (2010) Migration of breast cancer cells : understanding the roles of volume exclusion and cell-to-cell adhesion. Physical Review E (PRE), 82(4), 041901-1---41901-9.
We study MCF-7 breast cancer cell movement in a transwell apparatus. Various experimental conditions lead to a variety of monotone and nonmonotone responses which are difficult to interpret. We anticipate that the experimental results could be caused by cell-to-cell adhesion or volume exclusion. Without any modeling, it is impossible to understand the relative roles played by these two mechanisms. A lattice-based exclusion process random-walk model incorporating agent-to-agent adhesion is applied to the experimental system. Our combined experimental and modeling approach shows that a low value of cell-to-cell adhesion strength provides the best explanation of the experimental data suggesting that volume exclusion plays a more important role than cell-to-cell adhesion. This combined experimental and modeling study gives insight into the cell-level details and design of transwell assays.
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|Item Type:||Journal Article|
|Keywords:||Breast Cancer, Exclusion process, Transwell, Adhesion|
|Subjects:||Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Mathematical Sciences
|Copyright Owner:||Copyright 2010 The American Physical Society|
|Deposited On:||01 Dec 2010 07:48|
|Last Modified:||01 Mar 2012 00:27|
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