Migration of breast cancer cells : understanding the roles of volume exclusion and cell-to-cell adhesion

Simpson, Matthew, Towne, Chris L., McElwain, Sean, & Upton, Zee (2010) Migration of breast cancer cells : understanding the roles of volume exclusion and cell-to-cell adhesion. Physical Review E (PRE), 82(4), 041901-1---41901-9.

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We study MCF-7 breast cancer cell movement in a transwell apparatus. Various experimental conditions lead to a variety of monotone and nonmonotone responses which are difficult to interpret. We anticipate that the experimental results could be caused by cell-to-cell adhesion or volume exclusion. Without any modeling, it is impossible to understand the relative roles played by these two mechanisms. A lattice-based exclusion process random-walk model incorporating agent-to-agent adhesion is applied to the experimental system. Our combined experimental and modeling approach shows that a low value of cell-to-cell adhesion strength provides the best explanation of the experimental data suggesting that volume exclusion plays a more important role than cell-to-cell adhesion. This combined experimental and modeling study gives insight into the cell-level details and design of transwell assays.

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29 citations in Web of Science®

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158 since deposited on 30 Nov 2010
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ID Code: 38944
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Breast Cancer, Exclusion process, Transwell, Adhesion
DOI: 10.1103/PhysRevE.82.041901
ISSN: 1539-3755
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Mathematical Sciences
Copyright Owner: Copyright 2010 The American Physical Society
Deposited On: 30 Nov 2010 21:48
Last Modified: 29 Feb 2012 14:27

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