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Development of a PDLLA-based stereolithography resin for making tissue engineering scaffolds

Melchels, F.P.W., Grijpma, D.W., & Feijen, J. (2007) Development of a PDLLA-based stereolithography resin for making tissue engineering scaffolds. In 16th Annual Meeting of the Netherlands Society for Biomaterials and Tissue Engineering, 2007, Lunteren, Netherlands.

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Abstract

The use of porous structures as tissue engineering scaffolds imposes high demands on the pore architecture. Stereolithography is a rapid prototyping method based on photo-polymerisation, that can be utilised to make 3D constructs with high spatial control. In this study, biodegradable resins were developed that can find application in stereolithography. Poly(D,L-lactide) (PDLLA) oligomers were synthesised and functionalised with methacrylate end-groups. By mixing the resulting macromers with a diluent, photo-initiator and inhibitor, lowviscosity resins were obtained that were photocrosslinked to yield stiff and strong degradable poly(lactide) networks. Also, porous scaffolds were fabricated on a stereolithography apparatus (SLA) from a nondegradable resin.

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ID Code: 38980
Item Type: Conference Paper
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2007 Please consult the authors.
Deposited On: 02 Dec 2010 03:39
Last Modified: 04 Jul 2012 00:52

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