Perfusion model system to generate engineered grafts with controlled cellular distributions

Tonnarelli, Beatrice, Melchels, Ferry P.W., Olivares, Andy L., Lacroix, Damien, Grijpma, Dirk W., Martin, Ivan, & Wendt, David (2010) Perfusion model system to generate engineered grafts with controlled cellular distributions. In Annual Conference of the Tissue Engineering and Regenerative Medicine, Europe Chapter (TERMIS-EU 2010), 13-17 June 2010, Galway, Ireland.

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Engineered tissue grafts, which mimic the spatial variations of cell density and extracellular matrix present in native tissues, could facilitate more efficient tissue regeneration and integration. We previously demonstrated that cells could be uniformly seeded throughout a 3D scaffold having a random pore architecture using a perfusion bioreactor2. In this work, we aimed to generate 3D constructs with defined cell distributions based on rapid prototyped scaffolds manufactured with a controlled gradient in porosity. Computational models were developed to assess the influence of fluid flow, associated with pore architecture and perfusion regime, on the resulting cell distribution.

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ID Code: 39019
Item Type: Conference Paper
Refereed: Yes
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2010 Please consult the authors.
Deposited On: 03 Dec 2010 06:56
Last Modified: 04 Jul 2012 00:49

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