QUT ePrints

Perfusion model system to generate engineered grafts with controlled cellular distributions

Tonnarelli, Beatrice, Melchels, Ferry P.W., Olivares, Andy L., Lacroix, Damien, Grijpma, Dirk W., Martin, Ivan, & Wendt, David (2010) Perfusion model system to generate engineered grafts with controlled cellular distributions. In Annual Conference of the Tissue Engineering and Regenerative Medicine, Europe Chapter (TERMIS-EU 2010), 13-17 June 2010, Galway, Ireland.

[img] Conference Paper (PDF 326kB)
Accepted Version.

    View at publisher

    Abstract

    Engineered tissue grafts, which mimic the spatial variations of cell density and extracellular matrix present in native tissues, could facilitate more efficient tissue regeneration and integration. We previously demonstrated that cells could be uniformly seeded throughout a 3D scaffold having a random pore architecture using a perfusion bioreactor2. In this work, we aimed to generate 3D constructs with defined cell distributions based on rapid prototyped scaffolds manufactured with a controlled gradient in porosity. Computational models were developed to assess the influence of fluid flow, associated with pore architecture and perfusion regime, on the resulting cell distribution.

    Impact and interest:

    Citation countsare sourced monthly from Scopus and Web of Science® citation databases.

    These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

    Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

    Full-text downloads:

    74 since deposited on 03 Dec 2010
    24 in the past twelve months

    Full-text downloadsdisplays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

    ID Code: 39019
    Item Type: Conference Paper
    Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
    Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
    Current > Institutes > Institute of Health and Biomedical Innovation
    Past > Schools > School of Engineering Systems
    Copyright Owner: Copyright 2010 Please consult the authors.
    Deposited On: 03 Dec 2010 16:56
    Last Modified: 04 Jul 2012 10:49

    Export: EndNote | Dublin Core | BibTeX

    Repository Staff Only: item control page