QUT ePrints

A two-compartment mechanochemical model of the roles of transforming growth factor-beta and tissue tension in dermal wound healing

Murphy, Kelly E., Hall, Cameron L., McCue, Scott W., & McElwain, D.L. Sean (2011) A two-compartment mechanochemical model of the roles of transforming growth factor-beta and tissue tension in dermal wound healing. Journal of Theoretical Biology, 272(1), pp. 145-159.

View at publisher

Abstract

The repair of dermal tissue is a complex process of interconnected phenomena, where cellular, chemical and mechanical aspects all play a role, both in an autocrine and in a paracrine fashion. Recent experimental results have shown that transforming growth factor-beta (TGF-beta) and tissue mechanics play roles in regulating cell proliferation, differentiation and the production of extracellular materials. We have developed a 1D mathematical model that considers the interaction between the cellular, chemical and mechanical phenomena, allowing the combination of TGF-beta and tissue stress to inform the activation of fibroblasts to myofibroblasts. Additionally, our model incorporates the observed feature of residual stress by considering the changing zero-stress state in the formulation for effective strain. Using this model, we predict that the continued presence of TGF-beta in dermal wounds will produce contractures due to the persistence of myofibroblasts; in contrast, early elimination of TGF-beta significantly reduces the myofibroblast numbers resulting in an increase in wound size. Similar results were obtained by varying the rate at which fibroblasts differentiate to myofibroblasts and by changing the myofibroblast apoptotic rate. Taken together, the implication is that elevated levels of myofibroblasts is the key factor behind wounds healing with excessive contraction, suggesting that clinical strategies which aim to reduce the myofibroblast density may reduce the appearance of contractures.

Impact and interest:

11 citations in Scopus
Search Google Scholar™
10 citations in Web of Science®

Citation countsare sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

94 since deposited on 14 Dec 2010
7 in the past twelve months

Full-text downloadsdisplays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 39171
Item Type: Journal Article
Keywords: biomechanics, morphoelasticity, zero stress states, mathematical biology, wound healing, myofibroblasts, TGF-beta
DOI: 10.1016/j.jtbi.2010.12.011
ISSN: 0022-5193
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Mathematical Sciences
Copyright Owner: Copyright 2011 Please consult the authors.
Deposited On: 14 Dec 2010 14:53
Last Modified: 01 Mar 2012 00:28

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page