Mechanistic investigations into interactions between IGF-I and IGFBPs and their impact on facilitating cell migration on vitronectin

Kricker, Jennifer A., Hyde, Carolyn E., Van Lonkhuyzen, Derek R., Hollier, Brett G., Shooter, Gary K., Leavesley, David I., Herington, Adrian C., & Upton, Zee (2010) Mechanistic investigations into interactions between IGF-I and IGFBPs and their impact on facilitating cell migration on vitronectin. Growth Factors, 28(5), pp. 359-369.

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Numerous studies have reported links between insulin-like growth factors (IGFs) and the extra-cellular matrix protein vitronectin (VN). We ourselves have reported that IGF-I binds to VN via IGF-binding proteins (IGFBPs) to stimulate HaCaT and MCF-7 cell migration. Here, we detail the functional evaluation of IGFBP-1, -2, -3, -4 and -6 in the presence and absence of IGF-I and VN. The data presented here, combined with our prior data on IGFBP-5, suggest that IGFBP-3, -4 and -5 are the most effective at stimulating cell migration in combination with IGF-I and VN. In addition, we demonstrate that different regions within IGFBP-3 and -4 are critical for complex formation. Furthermore, we examine whether multi-protein complexes of IGF-I and IGFBPs associated with fibronectin and collagen IV are also able to enhance functional biological responses.

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10 citations in Scopus
8 citations in Web of Science®
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ID Code: 39214
Item Type: Journal Article
Refereed: Yes
Keywords: Vitronectin, IGF-I, IGFBP, cell migration, heparin-binding
DOI: 10.3109/08977194.2010.494603
ISSN: 0897-7194
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Research Centres > Science Research Centre
Copyright Owner: Copyright 2010 Informa Healthcare/Taylor & Francis.
Deposited On: 16 Dec 2010 04:49
Last Modified: 12 Jul 2017 09:01

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