Melt electrospinning of polycaprolactone and its blends with poly(ethylene glycol)

Detta, Nicola, Brown, Toby D., Edin, Fredrik K., Albrecht, Krystyna, Chiellini, Federica, Chiellini, Emo, Dalton, Paul D., & Hutmacher, Dietmar W. (2010) Melt electrospinning of polycaprolactone and its blends with poly(ethylene glycol). Polymer International, 59(11), pp. 1558-1562.

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Melt electrospinning is one aspect of electrospinning with relatively little published literature, although the technique avoids solvent accumulation and/or toxicity which is favoured in certain applications. In the study reported, we melt-electrospun blends of poly(ε-caprolactone) (PCL) and an amphiphilic diblock copolymer consisting of poly(ethylene glycol) and PCL segments (PEG-block-PCL). A custom-made electrospinning apparatus was built and various combinations of instrument parameters such as voltage and polymer feeding rate were investigated. Pure PEG-block-PCL copolymer melt electrospinning did not result in consistent and uniform fibres due to the low molecular weight, while blends of PCL and PEG-block-PCL, for some parameter combinations and certain weight ratios of the two components, were able to produce continuous fibres significantly thinner (average diameter of ca 2 µm) compared to pure PCL. The PCL fibres obtained had average diameters ranging from 6 to 33 µm and meshes were uniform for the lowest voltage employed while mesh uniformity decreased when the voltage was increased. This approach shows that PCL and blends of PEG-block-PCL and PCL can be readily processed by melt electrospinning to obtain fibrous meshes with varied average diameters and morphologies that are of interest for tissue engineering purposes. Copyright © 2010 Society of Chemical Industry

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ID Code: 39277
Item Type: Journal Article
Refereed: Yes
Keywords: electrospinning, amphiphilic polymer, block copolymer, tissue engineering
DOI: 10.1002/pi.2954
ISSN: 1097-0126
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 21 Dec 2010 02:09
Last Modified: 29 Feb 2012 14:27

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