Melt electrospinning of polycaprolactone and its blends with poly(ethylene glycol)
Detta, Nicola, Brown, Toby D., Edin, Fredrik K., Albrecht, Krystyna , Chiellini, Federica , Chiellini, Emo , Dalton, Paul D., & Hutmacher, Dietmar W. (2010) Melt electrospinning of polycaprolactone and its blends with poly(ethylene glycol). Polymer International, 59(11), pp. 1558-1562.
Melt electrospinning is one aspect of electrospinning with relatively little published literature, although the technique avoids solvent accumulation and/or toxicity which is favoured in certain applications. In the study reported, we melt-electrospun blends of poly(ε-caprolactone) (PCL) and an amphiphilic diblock copolymer consisting of poly(ethylene glycol) and PCL segments (PEG-block-PCL). A custom-made electrospinning apparatus was built and various combinations of instrument parameters such as voltage and polymer feeding rate were investigated. Pure PEG-block-PCL copolymer melt electrospinning did not result in consistent and uniform fibres due to the low molecular weight, while blends of PCL and PEG-block-PCL, for some parameter combinations and certain weight ratios of the two components, were able to produce continuous fibres significantly thinner (average diameter of ca 2 µm) compared to pure PCL. The PCL fibres obtained had average diameters ranging from 6 to 33 µm and meshes were uniform for the lowest voltage employed while mesh uniformity decreased when the voltage was increased. This approach shows that PCL and blends of PEG-block-PCL and PCL can be readily processed by melt electrospinning to obtain fibrous meshes with varied average diameters and morphologies that are of interest for tissue engineering purposes. Copyright © 2010 Society of Chemical Industry
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|Item Type:||Journal Article|
|Keywords:||electrospinning, amphiphilic polymer, block copolymer, tissue engineering|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering|
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||21 Dec 2010 12:09|
|Last Modified:||01 Mar 2012 00:27|
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