Age, muscle fatigue, and walking endurance in pre-menopausal women

Hunter, Gary R., Bickel, C. Scott, Corral, Pedro Del, Byrne, Nuala M., Hills, Andrew P., Larson-Meyer, D. Enette, Bamman, Marcas M., & Newcomer, Bradley R. (2010) Age, muscle fatigue, and walking endurance in pre-menopausal women. European Journal of Applied Physiology.

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Aging is associated with loss of endurance; however, aging is also associated with decreased fatigue during maximal isometric contractions. The aims of this study were to examine the relationship between age and walking endurance (WE) and maximal isometric fatigue (MIF) and to determine which metabolic/fitness components explain the expected age effects on WE and MIF. Subjects were 96 pre-menopausal women. Oxygen uptake (walking economy) was assessed during a 3-mph walk; aerobic capacity and WE by progressive treadmill test; knee extension strength by isometric contractions, MIF during a 90-s isometric plantar flexion (muscle metabolism measured by 31P MRS). Age was related to increased walking economy (low VO2, r = −0.19, P < 0.03) and muscle metabolic economy (force/ATP, 0.34, P = 0.01), and reduced MIF (−0.26, P < 0.03). However, age was associated with reduced WE (−0.28, P < 0.01). Multiple regression showed that muscle metabolic economy explained the age-related decrease in MIF (partial r for MIF and age −0.13, P = 0.35) whereas walking economy did not explain the age-related decrease in WE (partial r for WE and age −0.25, P < 0.02). Inclusion of VO2max and knee endurance strength accounted for the age-related decreased WE (partial r for WE and age = 0.03, P > 0.80). In premenopausal women, age is related to WE and MIF. In addition, these results support the hypothesis that age-related increases in metabolic economy may decrease MIF. However, decreased muscle strength and oxidative capacity are related to WE.

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4 citations in Scopus
2 citations in Web of Science®
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ID Code: 39689
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Exercise Economy, Oxygen Uptake, Muscular Strength, Function
DOI: 10.1007/s00421-010-1694-1
ISSN: 1439-6319
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600)
Divisions: Past > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Springer-Verlag
Deposited On: 26 Jan 2011 22:59
Last Modified: 12 Jul 2017 12:01

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