PLGA-based microparticles for the sustained release of BMP-2
Kirby, Giles , White, Lisa, Rahman, Cheryl , Cox, Helen , Qutachi, Omar , Rose, Felicity , Hutmacher, Dietmar W., Shakesheff, Kevin , & Woodruff, Maria A. (2011) PLGA-based microparticles for the sustained release of BMP-2. Polymers, 3(1), pp. 571-586.
The development of growth factor delivery strategies to circumvent the burst release phenomenon prevalent in most current systems has driven research towards encapsulating molecules in resorbable polymer matrices. For these polymer release techniques to be efficacious in a clinical setting, several key points need to be addressed. This present study has investigated the encapsulation of the growth factor, BMP-2 within PLGA/PLGA-PEG-PLGA microparticles. Morphology, size distribution, encapsulation efficiency and release kinetics were investigated and we have demonstrated a sustained release of bioactive BMP-2. Furthermore, biocompatibility of the PLGA microparticles was established and released BMP-2 was shown to promote the differentiation of MC3T3-E1 cells towards the osteogenic lineage to a greater extent than osteogenic supplements (as early as day 10 in culture), as determined using alkaline phosphatase and alizarin red assays. This study showcases a potential BMP-2 delivery system which may now be translated into more complex delivery systems, such as 3D, mechanically robust scaffolds for bone tissue regeneration applications.
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|Item Type:||Journal Article|
|Keywords:||PLGA, BMP2, microspheres, MC3T3, controlled release|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering|
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2011 The Authors|
|Copyright Statement:||Copyright 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).|
|Deposited On:||28 Feb 2011 07:37|
|Last Modified:||04 Nov 2013 13:06|
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