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Multivariate Markov Process Models for the transmission of methicillin-resistant Staphylococcus Aureus in a hospital ward

Drovandi, Christopher C. & Pettitt, Anthony N. (2008) Multivariate Markov Process Models for the transmission of methicillin-resistant Staphylococcus Aureus in a hospital ward. Biometrics, 64(3), pp. 851-859.

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Abstract

Methicillin-resistant Staphylococcus Aureus (MRSA) is a pathogen that continues to be of major concern in hospitals. We develop models and computational schemes based on observed weekly incidence data to estimate MRSA transmission parameters. We extend the deterministic model of McBryde, Pettitt, and McElwain (2007, Journal of Theoretical Biology 245, 470–481) involving an underlying population of MRSA colonized patients and health-care workers that describes, among other processes, transmission between uncolonized patients and colonized health-care workers and vice versa. We develop new bivariate and trivariate Markov models to include incidence so that estimated transmission rates can be based directly on new colonizations rather than indirectly on prevalence. Imperfect sensitivity of pathogen detection is modeled using a hidden Markov process. The advantages of our approach include (i) a discrete valued assumption for the number of colonized health-care workers, (ii) two transmission parameters can be incorporated into the likelihood, (iii) the likelihood depends on the number of new cases to improve precision of inference, (iv) individual patient records are not required, and (v) the possibility of imperfect detection of colonization is incorporated. We compare our approach with that used by McBryde et al. (2007) based on an approximation that eliminates the health-care workers from the model, uses Markov chain Monte Carlo and individual patient data. We apply these models to MRSA colonization data collected in a small intensive care unit at the Princess Alexandra Hospital, Brisbane, Australia.

Impact and interest:

4 citations in Scopus
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4 citations in Web of Science®

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ID Code: 40440
Item Type: Journal Article
Keywords: Binomial observation, Colonization, Discrete data, Hidden Markov model, Hospital epidemiology, Incidence, Infection, Markov process, Prevalence, Susceptible/Infective model, Time series
DOI: 10.1111/j.1541-0420.2007.00933.x
ISSN: 0006-341X
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > STATISTICS (010400)
Divisions: Past > Schools > Mathematical Sciences
Copyright Owner: Copyright 2008 Wiley-Blackwell Publishing Ltd.
Deposited On: 04 Mar 2011 09:44
Last Modified: 29 Feb 2012 23:40

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