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A DRD2 polymorphism predicts PANSS score variability in schizophrenia patients treated with antipsychotics

Voisey, Joanne, Swagell, Christopher D., Hughes, Ian P., Barnes, Mark, Burton, Simon C., van Daal, Angela M., Morris, C. Phillip, Lawford, Bruce R., & Young, Ross McD. (2010) A DRD2 polymorphism predicts PANSS score variability in schizophrenia patients treated with antipsychotics. Psychiatry Research, 177(3), pp. 367-368.

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Abstract

Antipsychotic medications act as either antagonists or partial agonists of the dopamine D2 receptor (DRD2) and antipsychotic drugs vary widely in their binding affinity for the D2 receptor (Kapur and Seeman, 2000). The DRD2 957CNT (rs6277) polymorphism has previously been associated with schizophrenia (Lawford et al., 2005) and the T-allele of the 957CNT polymorphism is associated with reduced mRNA stability and synthesis of the dopamine D2 receptor (Duan et al., 2003). The aim of the study was to determine if the rs6277 polymorphism predicts some of the variability of positive and negative symptoms observed in schizophrenia patients being treated with antipsychotic medication.

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ID Code: 40589
Item Type: Journal Article
Keywords: Dopamine, Genotype, Psychological Disorder, Medication, Genetics
DOI: 10.1016/j.psychres.2010.02.015
ISSN: 0165-1781
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Neurogenetics (060410)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Mental Health (111714)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > COGNITIVE SCIENCE (170200)
Divisions: Past > Schools > Cell & Molecular Biosciences
Current > QUT Faculties and Divisions > Faculty of Health
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Copyright Owner: Copyright © 2010 Elsevier Ltd All rights reserved.
Deposited On: 09 Mar 2011 11:25
Last Modified: 19 Jan 2012 15:33

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