Dysbindin (DTNBP1) : a role in psychotic depression?

Domschke, Katharina, Lawford, Bruce R., Young, Ross McD., Voisey, Joanne, Morris, C. Phillip, Roehrs, Tilmann, Hohoff, Christa, Birosova, Eva, Arolt, Volker, & Baune, Bernhard T. (2010) Dysbindin (DTNBP1) : a role in psychotic depression? Journal of Psychiatric Research.

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Previous studies yielded evidence for dysbindin (DTNBP1) to impact the pathogenesis of schizophrenia on the one hand and affective disorders such as bipolar or major depressive disorder (MDD) on the other. Thus, in the present study we investigated whether DTNBP1 variation was associated with psychotic depression as a severe clinical manifestation of MDD possibly constituting an overlapping phenotype between affective disorders and schizophrenia.

A sample of 243 Caucasian inpatients with MDD (SCID-I) was genotyped for 12 SNPs spanning 92% of the DTNBP1 gene region. Differences in DTNBP1 genotype distributions across diagnostic subgroups of psychotic (N = 131) vs. non-psychotic depression were estimated by Pearson Chi2 test and logistic regression analyses adjusted for age, gender, Beck Depression Inventory (BDI) and the Global Assessment of Functioning Scale (GAF).

Overall, patients with psychotic depression presented with higher BDI and lower GAF scores expressing a higher severity of the illness as compared to depressed patients without psychotic features. Four DTNBP1 SNPs, particularly rs1997679 and rs9370822, and the corresponding haplotypes, respectively, were found to be significantly associated with the risk of psychotic depression in an allele-dose fashion.

In summary, the present results provide preliminary support for dysbindin (DTNBP1) gene variation, particularly SNPs rs1997679 and rs9370822, to be associated with the clinical phenotype of psychotic depression suggesting a possible neurobiological mechanism for an intermediate trait on the continuum between affective disorders and schizophrenia.

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ID Code: 40596
Item Type: Journal Article
Refereed: Yes
Keywords: Major depression; Psychotic depression; Genetic; Dysbindin; DTNBP1; Glutamate
DOI: 10.1016/j.jpsychires.2010.09.014
ISSN: 0022-3956
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Elsevier
Deposited On: 09 Mar 2011 01:45
Last Modified: 10 Aug 2011 17:08

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