INTS3 controls the hSSB1-mediated DNA damage response
Skaar, Jeffrey R. , Richard, Derek J., Saraf, Anita , Toschi, Alfredo , Bolderson, Emma, Florens, Laurence , Washburn, Michael P. , Khanna, Kum Kum, & Pagano, c (2009) INTS3 controls the hSSB1-mediated DNA damage response. The Journal of Cell Biology, 187(1), pp. 25-32.
Human SSB1 (single-stranded binding protein 1 [hSSB1]) was recently identified as a part of the ataxia telangiectasia mutated (ATM) signaling pathway. To investigate hSSB1 function, we performed tandem affinity purifications of hSSB1 mutants mimicking the unphosphorylated and ATM-phosphorylated states. Both hSSB1 mutants copurified a subset of Integrator complex subunits and the uncharacterized protein LOC58493/c9orf80 (henceforth minute INTS3/hSSB-associated element [MISE]). The INTS3–MISE–hSSB1 complex plays a key role in ATM activation and RAD51 recruitment to DNA damage foci during the response to genotoxic stresses. These effects on the DNA damage response are caused by the control of hSSB1 transcription via INTS3, demonstrating a new network controlling hSSB1 function.
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|Item Type:||Journal Article|
|Keywords:||ataxia telangiectasia mutated, homologous recombination, minute INTS3/hSSB-associated element|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
|Copyright Owner:||Copyright 2009 The Authors|
|Copyright Statement:||This article is distributed under the terms of an Attribution– Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).|
|Deposited On:||10 Mar 2011 09:45|
|Last Modified:||01 Mar 2012 00:31|
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